The Long-Term Prognostic Significance of Circulating Tumor Cells in Ovarian Cancer-A Study of the OVCAD Consortium.

ABSTRACT:

Introduction

We previously reported the prognostic impact of circulating tumor cells (CTCs) in a multicenter study on minimal residual disease in primary ovarian cancer. With additional follow-up data, we evaluated the combined CTC approach (CTCs^combo), in particular for the patients who had survived more than five years.

Material and methods

Blood samples taken at baseline and six months after adjuvant treatment (follow-up) were assessed by quantitative PCR (qPCR) measuring PPIC transcripts and immunofluorescent staining (IF). A positive result with either IF or qPCR was classified as CTC^combo-positive. Further, PPIC was assessed in the primary tumor tissue.

Results

The concordance of IF and qPCR was 65% at baseline and 83% after treatment. Resu

SUBMITTER: Obermayr E 

PROVIDER: S-EPMC8198007 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature