Vitamin D: Promises on the Horizon and Challenges Ahead for Fighting Pancreatic Cancer.

ABSTRACT: Pancreatic cancer has a dismal prognosis, while its incidence is increasing. This is attributed, in part, to a profound desmoplastic and immunosuppressive tumor microenvironment associated with this cancer and resistance to current available therapies. Novel and effective intervention strategies are urgently needed to improve the outcomes of patients with pancreatic cancer. Vitamin D has pleiotropic functions beyond calcium-phosphate homeostasis and has been extensively studied both in the laboratory and clinic as a potential preventive agent or adjunct to standard therapies. Accumulating evidence from ecological, observational, and randomized controlled trials suggests that vitamin D has beneficial effects on risk, survival, and mortality in pancreatic cancer, although controversies still

SUBMITTER: Wei D 

PROVIDER: S-EPMC8198176 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature