Ontology highlight
ABSTRACT:
SUBMITTER: Feng L
PROVIDER: S-EPMC8198214 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Feng Li L Yu Shujia S Wang Hai H Yang Shengwei S Li Xue X Dai Hongjuan H Zhao Liwen L Jiang Cheng C Wang Yazhou Y
Molecules (Basel, Switzerland) 20210525 11
As a significant co-activator involved in cell cycle and cell growth, differentiation and development, p300/CBP has shown extraordinary potential target in cancer therapy. Herein we designed new compounds from the lead compound A-485 based on molecular dynamic simulations. A series of new spirocyclic chroman derivatives was prepared, characterized and proven to be a potential treatment of prostate cancer. The most potent compound <b>B16</b> inhibited the proliferation of enzalutamide-resistant 2 ...[more]