Mitochondrial Retrograde Signaling Contributes to Metabolic Differentiation in Yeast Colonies.

ABSTRACT: During development of yeast colonies, various cell subpopulations form, which differ in their properties and specifically localize within the structure. Three branches of mitochondrial retrograde (RTG) signaling play a role in colony development and differentiation, each of them activating the production of specific markers in different cell types. Here, aiming to identify proteins and processes controlled by the RTG pathway, we analyzed proteomes of individual cell subpopulations from colonies of strains, mutated in genes of the RTG pathway. Resulting data, along with microscopic analyses revealed that the RTG pathway predominantly regulates processes in U cells, long-lived cells with unique properties, which are localized in upper colony regions. Rtg proteins therein activate processes l

SUBMITTER: Plocek V 

PROVIDER: S-EPMC8198273 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature