The Microbiota and the Gut-Brain Axis in Controlling Food Intake and Energy Homeostasis.

ABSTRACT: Obesity currently represents a major societal and health challenge worldwide. Its prevalence has reached epidemic proportions and trends continue to rise, reflecting the need for more effective preventive measures. Hypothalamic circuits that control energy homeostasis in response to food intake are interesting targets for body-weight management, for example, through interventions that reinforce the gut-to-brain nutrient signalling, whose malfunction contributes to obesity. Gut microbiota-diet interactions might interfere in nutrient sensing and signalling from the gut to the brain, where the information is processed to control energy homeostasis. This gut microbiota-brain crosstalk is mediated by metabolites, mainly short chain fatty acids, secondary bile acids or amino acids-derived metab

SUBMITTER: Romani-Perez M 

PROVIDER: S-EPMC8198395 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature