Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys.

ABSTRACT: Degeneration of dopamine (DA) neurons in the midbrain underlies the pathogenesis of Parkinson's disease (PD). Supplement of DA via L-DOPA alleviates motor symptoms but does not prevent the progressive loss of DA neurons. A large body of experimental studies, including those in nonhuman primates, demonstrates that transplantation of fetal mesencephalic tissues improves motor symptoms in animals, which culminated in open-label and double-blinded clinical trials of fetal tissue transplantation for PD¹. Unfortunately, the outcomes are mixed, primarily due to the undefined and unstandardized donor tissues^1,2. Generation of induced pluripotent stem cells enables standardized and autologous transplantation therapy for PD. However, its efficacy, especially in primates, remain

SUBMITTER: Tao Y 

PROVIDER: S-EPMC8198752 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature