Zebrafish as a Model for the Study of Lipid-Lowering Drug-Induced Myopathies.

ABSTRACT: Drug-induced myopathies are classified as acquired myopathies caused by exogenous factors. These pathological conditions develop in patients without muscle disease and are triggered by a variety of medicaments, including lipid-lowering drugs (LLDs) such as statins, fibrates, and ezetimibe. Here we summarise the current knowledge gained via studies conducted using various models, such as cell lines and mammalian models, and compare them with the results obtained in zebrafish (Danio rerio) studies. Zebrafish have proven to be an excellent research tool for studying dyslipidaemias as a model of these pathological conditions. This system enables in-vivo characterization of drug and gene candidates to further the understanding of disease aetiology and develop new therapeutic strategies.

SUBMITTER: Dubinska-Magiera M 

PROVIDER: S-EPMC8198905 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature