Nitrate- and Nitrite-Sensing Histidine Kinases: Function, Structure, and Natural Diversity.

ABSTRACT: Under anaerobic conditions, bacteria may utilize nitrates and nitrites as electron acceptors. Sensitivity to nitrous compounds is achieved via several mechanisms, some of which rely on sensor histidine kinases (HKs). The best studied nitrate- and nitrite-sensing HKs (NSHKs) are NarQ and NarX from Escherichia coli. Here, we review the function of NSHKs, analyze their natural diversity, and describe the available structural information. In particular, we show that around 6000 different NSHK sequences forming several distinct clusters may now be found in genomic databases, comprising mostly the genes from Beta- and Gammaproteobacteria as well as from Bacteroidetes and Chloroflexi, including those from anaerobic ammonia oxidation (annamox) communities. We sho

SUBMITTER: Gushchin I 

PROVIDER: S-EPMC8199190 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature