Oral Microbiome in Relation to Periodontitis Severity and Systemic Inflammation.

ABSTRACT: Systemic inflammation induced by periodontitis is suggested to be the link between periodontitis and cardiovascular disease. The aim of this work was to explore the oral microbiome in periodontitis in relation to disease severity and systemic inflammation. The saliva and subgingival microbiome from periodontal pocket samples of patients with severe (n = 12) and mild periodontitis (n = 13) were analyzed using metagenomic shotgun sequencing. The taxa and pathways abundances were quantified. The diversity was assessed and the abundances to phenotype associations were performed using ANCOM and linear regression. A panel of inflammatory markers was measured in blood and was associated with taxa abundance. The microbial diversity and species richness did not differ between severe and mild period

SUBMITTER: Plachokova AS 

PROVIDER: S-EPMC8199296 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature