Mitochondrial Dysfunction in Atrial Fibrillation-Mechanisms and Pharmacological Interventions.

ABSTRACT: Despite the enormous progress in the treatment of atrial fibrillation, mainly with the use of invasive techniques, many questions remain unanswered regarding the pathomechanism of the arrhythmia and its prevention methods. The development of atrial fibrillation requires functional changes in the myocardium that result from disturbed ionic fluxes and altered electrophysiology of the cardiomyocyte. Electrical instability and electrical remodeling underlying the arrhythmia may result from a cellular energy deficit and oxidative stress, which are caused by mitochondrial dysfunction. The significance of mitochondrial dysfunction in the pathogenesis of atrial fibrillation remains not fully elucidated; however, it is emphasized by the reduction of atrial fibrillation burden after therapeutic inte

SUBMITTER: Muszynski P 

PROVIDER: S-EPMC8199309 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature