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Photoredox Catalyzed Dealkylative Aromatic Halogen Substitution with Tertiary Amines.

ABSTRACT: A reaction of aromatic halides bearing electron-withdrawing groups with tertiary amines in the presence of an iridium catalyst under blue light irradiation is described. Products of the aromatic substitution of the halide by the dialkylamino fragment are obtained. The interaction of aryl radicals with tertiary amines to generate zwitterionic radical species is believed to be the key factor responsible for the reaction efficiency.

SUBMITTER: Lipilin DL

PROVIDER: S-EPMC8199326 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Photoredox Catalyzed Dealkylative Aromatic Halogen Substitution with Tertiary Amines.

Lipilin Dmitry L DL Frumkin Alexander E AE Tyurin Alexey Y AY Levin Vitalij V VV Dilman Alexander D AD

Molecules (Basel, Switzerland) 20210601 11

A reaction of aromatic halides bearing electron-withdrawing groups with tertiary amines in the presence of an iridium catalyst under blue light irradiation is described. Products of the aromatic substitution of the halide by the dialkylamino fragment are obtained. The interaction of aryl radicals with tertiary amines to generate zwitterionic radical species is believed to be the key factor responsible for the reaction efficiency. ...[more]

PMID: 34205980

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