Surgery after Induction Targeted Therapy and Immunotherapy for Lung Cancer.

ABSTRACT: Multimodality therapy for locally advanced non-small cell lung cancer (NSCLC) is a complex and controversial issue, especially regarding optimal treatment regimens for patients with ipsilateral positive mediastinal nodes (N2 disease). Many trials investigating neoadjuvant immunotherapy and targeted therapy in this subpopulation have shown promising results, although concerns have risen regarding surgical feasibility. A thorough literature review was performed, analyzing all recent studies regarding surgical morbidity and mortality. Despite the fact that two major trials investigating this subject were terminated early, the overall consensus is that surgical management seems feasible. However, dissection of hilar vessels may be challenging due to hilar fibrosis. Further research is necessar

SUBMITTER: Allaeys T 

PROVIDER: S-EPMC8199385 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature