Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M^pro) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus.

ABSTRACT: In December 2020, the U.K. authorities reported to the World Health Organization (WHO) that a new COVID-19 variant, considered to be a variant under investigation from December 2020 (VUI-202012/01), was identified through viral genomic sequencing. Although several other mutants were previously reported, VUI-202012/01 proved to be about 70% more transmissible. Hence, the usefulness and effectiveness of the newly U.S. Food and Drug Administration (FDA)-approved COVID-19 vaccines against these new variants are doubtfully questioned. As a result of these unexpected mutants from COVID-19 and due to lack of time, much research interest is directed toward assessing secondary metabolites as potential candidates for developing lead pharmaceuticals. In this study, a marine-derived fungus Aspergil

SUBMITTER: Uras IS 

PROVIDER: S-EPMC8199578 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature