Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients.

ABSTRACT: Metastasis continues to be the primary cause of all cancer-related deaths despite the recent advancements in cancer treatments. To evaluate the role of mutations in overall survival (OS) and treatment outcomes, we analyzed 957 metastatic patients with seven major cancer types who had available molecular testing results with a FoundationOne CDx^® panel. The most prevalent genes with somatic mutations were TP53, KRAS, APC, and LRP1B. In this analysis, these genes had mutation frequencies higher than in publicly available datasets. We identified that the somatic mutations were seven mutually exclusive gene pairs and an additional fifty-two co-occurring gene pairs. Mutations in the mutually exclusive gene pair APC and CDKN2A showed an opposit

SUBMITTER: Roosan MR 

PROVIDER: S-EPMC8199748 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature