A re-testing range is recommended for ¹³C- and ¹⁴C-urea breath tests for Helicobacter pylori infection in China.

ABSTRACT:

Background

The urea breath test (UBT) is widely used for diagnosing Helicobacter pylori infection. In the Shenzhen Kuichong People's Hospital, some UBT findings were contradictory to the histology outcomes, therefore this study aimed to assess and compare the diagnostic performance of both ¹³C- and ¹⁴C-UBT assays.

Methods

We recruited 484 H. pylori-treatment naïve patients, among which 217 and 267 were tested by the ¹³C-UBT or ¹⁴C-UBT, respectively. The cutoff value for H. pylori positivity based on manufacturer's instruction was 4% delta over baseline (DOB) for the ¹³C-UBT, and 100 disintegrations per minute (DPM) for the ¹⁴C-UBT. Gastric biopsies of the antrum and corpus were obtained during endoscopy for hi

SUBMITTER: Wang X 

PROVIDER: S-EPMC8199820 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature