Lung function trajectories and bronchial hyperresponsiveness during childhood following severe RSV bronchiolitis in infancy.

ABSTRACT:

Background

Children with severe respiratory syncytial virus (RSV) bronchiolitis in infancy have increased risks of asthma and reduced lung function in later life. There are limited studies on the longitudinal changes of lung function and bronchial hyperreactivity from early to late childhood in infants hospitalized for RSV bronchiolitis.

Methods

In a prospective cohort of 206 children with their first episode of RSV-confirmed bronchiolitis in the first year of life, 122 had spirometry performed at least twice between 5-16 years of age. Methacholine bronchoprovocation was available in 127 and 79 children at 7 and 12 years of age, respectively. Longitudinal changes in FEV₁ , FVC, and FEV₁ /FVC z-scores and methacholine PC₂₀ were analyzed.

Re

SUBMITTER: Kitcharoensakkul M 

PROVIDER: S-EPMC8200049 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature