Current Modulation of Guanylate Cyclase Pathway Activity-Mechanism and Clinical Implications.

ABSTRACT: For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme; however, in the last few years, in light of preclinical and clinical trials, it became an interesting target for pharmacological intervention. There are several possible options leading to an increase in cyclic guanosine monophosphate concentrations. The first one is related to the uses of analogues of natriuretic peptides. The second is related to increasing levels of natriuretic peptides by the inhibition of degradation. The third leads to an increase in cyclic guanosine monophosphate concentration by the inhibition of its degradation by the inhibition of phosphodiesterase type 5. The last option involves increasing the concentration of cyclic guanosine monophosphate by the additional direct activation of

SUBMITTER: Grzesk G 

PROVIDER: S-EPMC8200204 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature