Drosophila, a powerful model to study virus-host interactions and pathogenicity in the fight against SARS-CoV-2.

ABSTRACT: The COVID-19 pandemic is having a tremendous impact on humanity. Although COVID-19 vaccines are showing promising results, they are not 100% effective and resistant mutant SARS-CoV-2 strains are on the rise. To successfully fight against SARS-CoV-2 and prepare for future coronavirus outbreaks, it is essential to understand SARS-CoV-2 protein functions, their host interactions, and how these processes convey pathogenicity at host tissue, organ and systemic levels. In vitro models are valuable but lack the physiological context of a whole organism. Current animal models for SARS-CoV-2 research are exclusively mammals, with the intrinsic limitations of long reproduction times, few progeny, ethical concerns and high maintenance costs. These limitations make them unsuitable for rapid functional

SUBMITTER: van de Leemput J 

PROVIDER: S-EPMC8200282 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature