The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets.

ABSTRACT: Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. Although most BCCs are easily managed, some are aggressive locally, require Mohs micrographic surgery, or can even metastasize. In the latter, resistance to Sonic Hedgehog inhibitors may occur. Despite their frequent occurrence in clinical practice, their transcriptional landscape remains poorly understood. By analyzing BCC RNA sequencing data according to clinically important features (all BCCs versus normal skin, high-risk versus low-risk BCCs based solely on histopathological subtypes with aggressive features, advanced versus non-advanced BCCs, and vismodegib-resistant versus vismodegib-sensitive tumors), we have identified novel differentially regulated genes and new targetable pathways implicated in BCC tu

SUBMITTER: Litvinov IV 

PROVIDER: S-EPMC8200290 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature