Template-based modeling by ClusPro in CASP13 and the potential for using co-evolutionary information in docking.

ABSTRACT: As a participant in the joint CASP13-CAPRI46 assessment, the ClusPro server debuted its new template-based modeling functionality. The addition of this feature, called ClusPro TBM, was motivated by the previous CASP-CAPRI assessments and by the proven ability of template-based methods to produce higher-quality models, provided templates are available. In prior assessments, ClusPro submissions consisted of models that were produced via free docking of pre-generated homology models. This method was successful in terms of the number of acceptable predictions across targets; however, analysis of results showed that purely template-based methods produced a substantially higher number of medium-quality models for targets for which there were good templates available. The addition of template-bas

SUBMITTER: Porter KA 

PROVIDER: S-EPMC8200321 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature