Sex-based Disparities in Hepatocellular Carcinoma Recurrence After Liver Transplantation.

ABSTRACT:

Background

Women with chronic liver disease have lower rates of hepatocellular carcinoma (HCC) as compared to men; it is unknown if there are sex-based differences in HCC recurrence postliver transplant.

Methods

We conducted an analysis of patients who underwent liver transplant for HCC in the United Network for Organ Sharing/Organ Procurement and Transplantation Network from January 1, 2012 through December 31, 2017.

Results

A total of 12 711 patients underwent liver transplant for HCC: 2909 (23%) women and 9802 (73%) men. Women had significantly lower rates of postliver transplant HCC recurrence than men (4.0% versus 5.4%, P = 0.002). A cox-regression analysis for postliver transplant HCC recurrence highlighted that even after accounting for etiology of cirrhosis, a

SUBMITTER: Cullaro G 

PROVIDER: S-EPMC8200371 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature