Transcriptomic meta-analysis of disuse muscle atrophy vs. resistance exercise-induced hypertrophy in young and older humans.

ABSTRACT:

Background

Skeletal muscle atrophy manifests across numerous diseases; however, the extent of similarities/differences in causal mechanisms between atrophying conditions in unclear. Ageing and disuse represent two of the most prevalent and costly atrophic conditions, with resistance exercise training (RET) being the most effective lifestyle countermeasure. We employed gene-level and network-level meta-analyses to contrast transcriptomic signatures of disuse and RET, plus young and older RET to establish a consensus on the molecular features of, and therapeutic targets against, muscle atrophy in conditions of high socio-economic relevance.

Methods

Integrated gene-level and network-level meta-analysis was performed on publicly available microarray data sets generated from youn

SUBMITTER: Deane CS 

PROVIDER: S-EPMC8200445 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature