Acute Exposure to Diesel Exhaust Increases Muscle Sympathetic Nerve Activity in Humans.

ABSTRACT: Background Diesel exhaust (DE) emissions are a major contributor to ambient air pollution and are strongly associated with cardiovascular morbidity and mortality. Exposure to traffic-related particulate matter is linked with acute adverse cardiovascular events; however, the mechanisms are not fully understood. We examined the role of the autonomic nervous system during exposure to DE that has previously only been indirectly investigated. Methods and Results Using microneurography, we measured muscle sympathetic nerve activity (MSNA) directly in the peroneal nerve of 16 healthy individuals. MSNA, heart rate, and respiration were recorded while subjects rested breathing filtered air, filtered air with an exposure mask, and standardized diluted DE (300 µg/m³) through the exposure m

SUBMITTER: Rankin GD 

PROVIDER: S-EPMC8200707 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature