A Retrospective Study on Using a Novel Single Needle Cone Puncture Approach for the Iodine-125 Seed Brachytherapy in Treating Patients With Thoracic Malignancy.

ABSTRACT:

Background

Patients with progressive thoracic malignancy characterized by large irregular tumors with necrosis and life-threatening symptoms lack effective treatments. We set out to develop a single needle cone puncture method for the Iodine-125 seed (SNCP-¹²⁵I) brachytherapy, and aim to report the initial results.

Methods

294 patients with advanced thoracic malignancy were treated with local SNCP-¹²⁵I brachytherapy between March 2009 and July 2020, followed by thorough evaluation of clinical outcome, overall survival (OS), progression-free survival (PFS) and procedure-related complications after treatment.

Results

The overall response rate (ORR) among the treated patients was 81.0% (238/294). Life-threatening symptoms due to tumor oppression, he

SUBMITTER: Li F 

PROVIDER: S-EPMC8200774 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature