Short-term effects of synchronized vs. non-synchronized NIPPV in preterm infants: study protocol for an unmasked randomized crossover trial.

ABSTRACT:

Background

Non-invasive ventilation (NIV) has been recommended as the best respiratory support for preterm infants with respiratory distress syndrome (RDS). However, the best NIV technique to be used as first intention in RDS management has not yet been established. Nasal intermittent positive pressure ventilation (NIPPV) may be synchronized (SNIPPV) or non-synchronized to the infant's breathing efforts. The aim of the study is to evaluate the short-term effects of SNIPPV vs. NIPPV on the cardiorespiratory events, trying to identify the best ventilation modality for preterm infants at their first approach to NIV ventilation support.

Methods

An unmasked randomized crossover study with three treatment phases was designed. All newborn infants < 32 weeks of gestational age with

SUBMITTER: Cresi F 

PROVIDER: S-EPMC8200781 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature