The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut.

ABSTRACT: Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds comprise histamine H1-receptor (H1R) antagonists, which are used to control allergic inflammation, antagonists at H2R, which therapeutically decrease gastric acid release, and an antagonist at H3R, which is indicated to treat narcolepsy. Ligands at H4R are still being tested pre-clinically and in clinical trials of inflammatory diseases, including rheumatoid arthritis, asthma, dermatitis, and psoriasis. These trials, however, documented only moderate beneficial effects of H4R ligands so far. Nevertheless, pre-clinically,

SUBMITTER: Schirmer B 

PROVIDER: S-EPMC8200986 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature