Targeting Tissue Factor to Tumor Vasculature to Induce Tumor Infarction.

ABSTRACT: Besides its central functional role in coagulation, TF has been described as being operational in the development of malignancies and is currently being studied as a possible therapeutic tool against cancer. One of the avenues being explored is retargeting TF or its truncated extracellular part (tTF) to the tumor vasculature to induce tumor vessel occlusion and tumor infarction. To this end, multiple structures on tumor vascular wall cells have been studied at which tTF has been aimed via antibodies, derivatives, or as bifunctional fusion protein through targeting peptides. Among these targets were vascular adhesion molecules, oncofetal variants of fibronectin, prostate-specific membrane antigens, vascular endothelial growth factor receptors and co-receptors, integrins, fibroblast activati

SUBMITTER: Berdel AF 

PROVIDER: S-EPMC8201357 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature