The GABA_A Receptor Influences Pressure Overload-Induced Heart Failure by Modulating Macrophages in Mice.

ABSTRACT:

Background

Myocardial macrophages have key roles in cardiac remodeling and dysfunction. The gamma-aminobutyric acid subtype A (GABA_A) receptor was recently found to be distributed in macrophages, allowing regulation of inflammatory responses to various diseases. This study aimed to clarify the role of GABA_A receptor-mediated macrophage responses in pressure overload-induced heart failure.

Methods and results

C57BL/6J mice underwent transverse aortic constriction for pressure-overload hypertrophy (POH) and were intraperitoneally treated with a specific GABA_A receptor agonist (topiramate) or antagonist (bicuculline). Echocardiography, histology, and flow cytometry were performed to evaluate the causes and effects of myocardial hypertrophy and f

SUBMITTER: Bu J 

PROVIDER: S-EPMC8201502 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature