Prognostic value of ferroptosis-related genes in patients with lung adenocarcinoma.

ABSTRACT:

Background

The prevalence of lung adenocarcinomas (LUADs) has dramatically increased in recent decades. Ferroptosis is a process of iron-dependent regulatory cell death. It is still unclear whether the expression of ferroptosis-related genes (FRGs) is involved in the pathogenesis and survival of patients with LUAD.

Methods

We retrieved LUAD data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and used LASSO Cox regression analysis to select the gene signature suitable for modeling. The risk score was calculated according to the model, and the patients were divided into high- and low-risk groups according to the median risk score. Functional enrichment analysis was carried out by this group, and a model for predicting clinical prognosis was est

SUBMITTER: Zhu G 

PROVIDER: S-EPMC8201541 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature