Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol.

ABSTRACT:

Background

Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models.

Methods

We will conduct a systematic review of comparative studies of red blood cell transfusion strategies using animal models of traumatic brain injury, ischemic stroke or cerebral hemorrhage. We will search MEDLINE, EMBASE, and Web of Science databases for eligible studies from inception onwards. Two independent reviewers will perform study selection and data extraction. We will report our results i

SUBMITTER: Laflamme M 

PROVIDER: S-EPMC8201673 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature