Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study.

ABSTRACT:

Background

Chronic brain pathology and pre-stroke cognitive impairment (PCI) is predictive of post-stroke dementia. The aim of the current study was to measure pre-stroke neurodegenerative and vascular disease burden found on brain MRI and to assess the association between pre-stroke imaging pathology and PCI, whilst also looking for potential sex differences.

Methods

This prospective brain MRI cohort is part of the multicentre Norwegian cognitive impairment after stroke (Nor-COAST) study. Patients hospitalized with acute ischemic or hemorrhagic stroke were included from five participating stroke units. Visual rating scales were used to categorize baseline MRIs (N = 410) as vascular, neurodegenerative, mixed, or normal, based on the presence of pathological imaging findings.

SUBMITTER: Schellhorn T 

PROVIDER: S-EPMC8201706 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature