Ontology highlight
ABSTRACT:
SUBMITTER: Orakov A
PROVIDER: S-EPMC8201837 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Orakov Askarbek A Fullam Anthony A Coelho Luis Pedro LP Khedkar Supriya S Szklarczyk Damian D Mende Daniel R DR Schmidt Thomas S B TSB Bork Peer P
Genome biology 20210613 1
Genomes are critical units in microbiology, yet ascertaining quality in prokaryotic genome assemblies remains a formidable challenge. We present GUNC (the Genome UNClutterer), a tool that accurately detects and quantifies genome chimerism based on the lineage homogeneity of individual contigs using a genome's full complement of genes. GUNC complements existing approaches by targeting previously underdetected types of contamination: we conservatively estimate that 5.7% of genomes in GenBank, 5.2% ...[more]