Ultrasound-guided nusinersen administration for spinal muscular atrophy patients with severe scoliosis: an observational study.

ABSTRACT:

Background

This observational study describes our experience delivering nusinersen through lumbar puncture with real-time ultrasound guidance in spinal muscular atrophy (SMA) patients with severe scoliosis.

Results

Intrathecal nusinersen via real-time ultrasound-guided lumbar puncture was given to three patients who had severe thoracic and lumbar scoliosis: a 34-year-old female with type 3a SMA, a 28-year-old male with type 2a SMA, and a 14-year-old girl with type 3a SMA. Lumbar puncture was performed without sedation under ultrasound guidance using a 22G echogenic needle in the interlaminar aspect of the L4-L5 or L5-S1 interspace and a full dose of nusinersen (12 mg/5 mL) was injected after visualizing free cerebrospinal fluid flow. Patients completed their four loading dos

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8201867 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature