Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells.

ABSTRACT:

Background

Human bone marrow-derived mesenchymal stem cells (hBMSCs) can differentiate into adipocytes upon stimulation and are considered an appropriate cell source for adipose tissue engineering. In addition to biochemical cues, the stiffness of a substrate that cells attach to has also been shown to affect hBMSC differentiation potential. Of note, most current studies are conducted on monolayer cultures which do not directly inform adipose tissue engineering, where 3-dimensional (3D) scaffolds are often used to create proper tissue architecture. In this study, we aim to examine the adipogenic differentiation of hBMSCs within soft or stiff scaffolds and investigate the molecular mechanism mediating the response of hBMSCs to substrate stiffness in 3D culture, specifically the invo

SUBMITTER: Xiang S 

PROVIDER: S-EPMC8201886 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature