Integrin α₂β₁-targeting ferritin nanocarrier traverses the blood-brain barrier for effective glioma chemotherapy.

ABSTRACT:

Background

Ferritin, the natural iron storage protein complex, self-assembles into a uniform cage-like structure. Human H-ferritin (HFn) has been shown to transverse the blood-brain barrier (BBB) by binding to transferrin receptor 1 (TfR1), which is abundant in endothelial cells and overexpressed in tumors, and enters cells via endocytosis. Ferritin is easily genetically modified with various functional molecules, justifying that it possesses great potential for development into a nanocarrier drug delivery system.

Results

In this study, a unique integrin α2β1-targeting H-ferritin (2D-HFn)-based drug delivery system was developed that highlights the feasibility of receptor-mediated transcytosis (RMT) for glioma tumor treatment. The integrin targeting α2β1 specificity was vali

SUBMITTER: Huang CW 

PROVIDER: S-EPMC8201891 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature