Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Rivera FJ
PROVIDER: S-EPMC8201929 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Sánchez-Rivera Francisco J FJ Ryan Jeremy J Soto-Feliciano Yadira M YM Clare Beytagh Mary M Xuan Lucius L Feldser David M DM Hemann Michael T MT Zamudio Jesse J Dimitrova Nadya N Letai Anthony A Jacks Tyler T
Proceedings of the National Academy of Sciences of the United States of America 20210601 23
Reactivation of p53 in established tumors typically results in one of two cell fates, cell cycle arrest or apoptosis, but it remains unclear how this cell fate is determined. We hypothesized that high mitochondrial priming prior to p53 reactivation would lead to apoptosis, while low priming would lead to survival and cell cycle arrest. Using a panel of Kras-driven, p53 restorable cell lines derived from genetically engineered mouse models of lung adenocarcinoma and sarcoma (both of which undergo ...[more]