Hypoxia-Induced miR-148a Downregulation Contributes to Poor Survival in Colorectal Cancer.

ABSTRACT: Hypoxia is an extensively investigated condition due to its contribution to various pathophysiological processes including cancer progression and metastasis formation. MicroRNAs (miRNAs) are well-known post-transcriptional gene expression regulators. However, their contribution to molecular response to hypoxia is highly dependent on cell/tissue types and causes of hypoxia. One of the most important examples is colorectal cancer, where no consensus on hypoxia-regulated miRNAs has been reached so far. In this work, we applied integrated mRNA and small RNA sequencing, followed by bioinformatics analysis, to study the landscape of hypoxia-induced miRNA and mRNA expression alterations in human colorectal cancer cell lines (HT-29 and Caco-2). A hypoxic microenvironment was chemically modeled usi

SUBMITTER: Nersisyan S 

PROVIDER: S-EPMC8202010 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature