Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients.

ABSTRACT: The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an importa

SUBMITTER: Bibert S 

PROVIDER: S-EPMC8202013 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature