Quantitative [¹⁸F]florbetapir PET/CT may identify lung involvement in patients with systemic AL amyloidosis.

ABSTRACT:

Purpose

The clinical diagnosis of pulmonary involvement in individuals with systemic AL amyloidosis remains challenging. [¹⁸F]florbetapir imaging has previously identified AL amyloid deposits in the heart and extra-cardiac organs. The aim of this study is to determine quantitative [¹⁸F]florbetapir pulmonary kinetics to identify pulmonary involvement in individuals with systemic AL amyloidosis.

Methods

We prospectively enrolled 58 subjects with biopsy-proven AL amyloidosis and 9 control subjects (5 without amyloidosis and 4 with ATTR cardiac amyloidosis). Pulmonary [¹⁸F]florbetapir uptake was evaluated visually and quantified as distribution volume of specific binding (Vs) derived from compartmental analysis and simpler semiquantitative metric

SUBMITTER: Khor YM 

PROVIDER: S-EPMC8202062 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature