Association Between Variation in Red Cell Size and Multiple Aging-Related Outcomes.

ABSTRACT:

Background

We tested whether greater variation in red blood cell size, measured by red cell distribution width (RDW), may predict aging-related degenerative conditions and therefore, serve as a marker of biological aging.

Methods

Three thousand six hundred and thirty-five community-dwelling older men were enrolled in the prospective Osteoporotic Fractures in Men Study. RDW was categorized into 4 groups (≤13.0%, 13.1%-14.0%, 14.1%-15.0%, and ≥15.1%). Functional limitations, frailty, strength, physical performance, and cognitive function were measured at baseline and 7.4 years later. Falls were recorded in the year after baseline; hospitalizations were obtained for 2 years after baseline. Mortality was assessed during a mean of 8.3 years of follow-up.

Results

Participan

SUBMITTER: Kim KM 

PROVIDER: S-EPMC8202142 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature