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Age of Peak Performance Differs by Functional Task in Mice Tracked Over 2 Years.

ABSTRACT: Mouse models are often used to validate novel interventions prior to human testing, although biological differences between mice and humans limit the translatability of outcomes. A common assumption in animal research is that maximal physical performance will be present at a young age, and that differences in task performance between young and old can be attributed to the aging process. However, this may not be true for all physical function tasks, and leaving out intermediate time points could drastically alter data interpretation. Here, we document age-related changes in forelimb and hindlimb grip strength, balance and coordination, and body composition in mice (n = 43) collected at multiple time points between 4 and 24 months of age. Maximal forelimb grip strength was recorded at 4 months of age, but maximal hindlimb grip strength was recorded at 15 months of age. Balance performance was stable from 4 to 15 months of age, declining significantly at 18 months. Both lean and fat mass peaked at 18 months before declining steadily. We conclude that the inclusion of intermediate time points is essential for the accurate evaluation of physical function status in mice, particularly in the context of translating intervention outcomes into strategies to be tested in humans.

SUBMITTER: Tavoian D

PROVIDER: S-EPMC8202156 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Age of Peak Performance Differs by Functional Task in Mice Tracked Over 2 Years.

Tavoian Dallin D Lozier Nicholas R NR de Lacalle Sonsoles S

The journals of gerontology. Series A, Biological sciences and medical sciences 20210601 7

Mouse models are often used to validate novel interventions prior to human testing, although biological differences between mice and humans limit the translatability of outcomes. A common assumption in animal research is that maximal physical performance will be present at a young age, and that differences in task performance between young and old can be attributed to the aging process. However, this may not be true for all physical function tasks, and leaving out intermediate time points could ...[more]

PMID: 33606019

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Project description:This article reports test-retest reliability data of laboratory- and field-based performance tests as well as body composition analyses of younger and older Kosovan adults. In total, 57 healthy young (18-35 years) and 61 older (>60 years) participants took part in two identical test sessions, with a median [25th - 75th percentile] of 14 [13-21] days in between. Functional performance tests included 30-s chair stand test (CST), 30-s arm curl test (ACT), six-minutes walking test (6MWT), sit and reach test, timed up and go test (TUG), as well as the assessment of gait speed (GS) at normal and fast pace. Isometric handgrip strength (HGS) was used to estimate strength of the dominant hand. Isokinetic peak torque (PT) and average power (AvgP) for knee extension and flexion were determined at velocities of 60°/s and 120°/s. Body composition assessments included body fat percentage, skeletal muscle mass (SMM) and index (SMI) as well as appendicular skeletal muscle mass (ASMM) and index. Secondary endpoints included self-perceived health status and potential co-morbidities. All performance test outcomes as well as body fat percentage, SMM, ASMM, and self-perceived health were significantly better in young as compared to older participants (p < 0.001). Improvements from test to retest were observed for CST (p < 0.001), PTflexion (60°/s: p = 0.001, 120°/s: p = 0.041), AvgPflexion (60°/s: p < 0.001, 120°/s: p < 0.001), AvgPextension (120°/s: p = 0.050), but also for SMM (p = 0.021) and SMI (p = 0.021). Only for CST and HGS a time x age group interaction was detected (p < 0.05). Acceptable reliability (ICC > 0.7) was observed for all parameters in both age groups, except for some of the measures from the isokinetic dynamometry, where ICCs were generally lower in older participants, but fell below 0.7 for AvgPflexion at 60°/s (ICC = 0.6) and at 120°/s (ICC = 0.67) as well as for PTflexion at 120°/s (ICC = 0.69). These data's importance lay upon their potential use in epidemiological studies observing muscle strength, peak torque, power, physical performance and body composition over various age groups, either in the same or similar populations, or for comparison to other populations.

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Age of Peak Performance Differs by Functional Task in Mice Tracked Over 2 Years.

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Age of Peak Performance Differs by Functional Task in Mice Tracked Over 2 Years.

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