Development and validation of ferroptosis-related lncRNAs signature for hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) with high heterogeneity is one of the most frequent malignant tumors throughout the world. However, there is no research to establish a ferroptosis-related lncRNAs (FRlncRNAs) signature for the patients with HCC. Therefore, this study was designed to establish a novel FRlncRNAs signature to predict the survival of patients with HCC.

Method

The expression profiles of lncRNAs were acquired from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database. FRlncRNAs co-expressed with ferroptosis-related genes were utilized to establish a signature. Cox regression was used to construct a novel three FRlncRNAs signature in the TCGA cohort, which was verified in the GEO validation cohort.

Results

Three differently expre

SUBMITTER: Liang J 

PROVIDER: S-EPMC8202323 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature