Molecular Characterization and Clinical Relevance of Lysine Acetylation Regulators in Urological Cancers.

ABSTRACT:

Background

Lysine acetylation and deacetylation are posttranslational modifications that are able to link extracellular signals to intracellular responses. However, knowledge regarding the status of lysine regulators in urological cancers is still unknown.

Methods

We first systematically analyzed the genetic and expression alterations of 31 lysine acetylation regulators in urological cancers. The correlation between lysine acetylation regulators and activation of cancer pathways was explored. The clinical relevance of lysine acetylation regulators was further analyzed.

Results

We identified that there are widespread genetic alterations of lysine acetylation regulators, and that their expression levels are significantly associated with the activity of cancer hallmark-r

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8202406 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature