Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons.

ABSTRACT: Extracellular magnesium ion ([Mg²⁺]) is a well-known voltage-dependent blocker of NMDA receptors, which plays a critical role in the regulation of neuronal plasticity, learning, and memory. It is generally believed that NMDA receptor activation involves in Mg²⁺ being removed into extracellular compartment from the channel pore. On the other hand, Mg²⁺ is one of the most abundant intracellular cations, and involved in numerous cellular functions. However, we do not know if extracellular magnesium ions can influx into neurons to affect intracellular signaling pathways. In our current study, we found that extracellular [Mg²⁺] elevation enhanced CREB activation by NMDA receptor signaling in both mixed sex rat cultured neurons and brain slices. Moreov

SUBMITTER: Hou H 

PROVIDER: S-EPMC8202957 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature