Vitamin D receptor polymorphisms and bone health after kidney transplantation

ABSTRACT:

Background/aim

Bone disease is one of the most prominent complications after kidney transplantation. Bone diseases include osteoporosis, persistent secondary hyperparathyroidism, and avascular necrosis (AVN). We investigated the relationship between the polymorphisms of the vitamin D receptor (VDR) gene and bone diseases occurring after kidney transplantation.

Materials and methods

The study consists of 234 kidney allograft recipients with a minimum follow-up of five years after kidney transplantation. Patients with glomerular filtration rates less than 30 mL/min/1.73m2, a history of parathyroidectomy, bisphosphonate use pre- or post-transplantation, and cinacalcet use posttransplantation excluded. We evaluated associations between the polymorphisms of the VDR gene (BsmI, Ta

SUBMITTER: Korucu B 

PROVIDER: S-EPMC8203162 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature