Ontology highlight
ABSTRACT:
SUBMITTER: Nicolas-Boluda A
PROVIDER: S-EPMC8203293 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Nicolas-Boluda Alba A Vaquero Javier J Vimeux Lene L Guilbert Thomas T Barrin Sarah S Kantari-Mimoun Chahrazade C Ponzo Matteo M Renault Gilles G Deptula Piotr P Pogoda Katarzyna K Bucki Robert R Cascone Ilaria I Courty José J Fouassier Laura L Gazeau Florence F Donnadieu Emmanuel E
eLife 20210609
Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing five preclinical mouse tumor models with heterogeneous tumor microenvironments, we aimed to relate the rate of tumor stiffening with the remodeling of ECM architecture and to determine how these features affect intratumoral T cell migration. An ECM-targeted strategy, based on the inhibition of lysyl oxidase, was ...[more]