Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC8203455 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Zhang Jing J Qin Yaowu Y Martinez Mireya M Flores-Bellver Miguel M Rodrigues Murilo M Dinabandhu Aumreetam A Cao Xuan X Deshpande Monika M Qin Yu Y Aparicio-Domingo Silvia S Rui Yuan Y Tzeng Stephany Y SY Salman Shaima S Yuan Jin J Scott Adrienne W AW Green Jordan J JJ Canto-Soler M Valeria MV Semenza Gregg L GL Montaner Silvia S Sodhi Akrit A
The Journal of clinical investigation 20210601 12
Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease. Here, we shift our attention upstream from the genes that promote retinal neovascularization (NV) to the transcription factors that regulate their expression. We demonstrated increased expression of HIF-1α and HIF-2α in the ischemic inner retina of PSR eyes. Although both HIFs participated in promoting ...[more]