Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.

ABSTRACT: Severe asthma remains challenging to manage and has limited treatment options. We have previously shown that targeting smooth muscle integrin α5β1 interaction with fibronectin can mitigate the effects of airway hyperresponsiveness by impairing force transmission. In this study, we show that another member of the integrin superfamily, integrin α2β1, is present in airway smooth muscle and capable of regulating force transmission via cellular tethering to the matrix protein collagen I and, to a lesser degree, laminin-111. The addition of an inhibitor of integrin α2β1 impaired IL-13-enhanced contraction in mouse tracheal rings and human bronchial rings and abrogated the exaggerated bronchoconstriction induced by allergen sensitization and challenge. We confirmed that this effect was not due to

SUBMITTER: Liu S 

PROVIDER: S-EPMC8203456 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature