Animal models for pelvic organ prolapse: systematic review.

ABSTRACT:

Introduction and hypothesis

We aimed to summarize the knowledge on the pathogenesis of pelvic organ prolapse (POP) generated in animal models.

Methods

We searched MEDLINE, Embase, Cochrane and the Web of Science to establish what animal models are used in the study of suggested risk factors for the development of POP, including pregnancy, labor, delivery, parity, aging and menopause. Lack of methodologic uniformity precluded meta-analysis; hence, results are presented as a narrative review.

Results

A total of 7426 studies were identified, of which 51 were included in the analysis. Pregnancy has a measurable and consistent effect across species. In rats, simulated vaginal delivery induces structural changes in the pelvic floor, without complete recovery of the vaginal

SUBMITTER: Mori da Cunha MGMC 

PROVIDER: S-EPMC8203535 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature