Facile fabrication of antibacterial and antiviral perhydrolase-polydopamine composite coatings.

ABSTRACT: In situ generation of antibacterial and antiviral agents by harnessing the catalytic activity of enzymes on surfaces provides an effective eco-friendly approach for disinfection. The perhydrolase (AcT) from Mycobacterium smegmatis catalyzes the perhydrolysis of acetate esters to generate the potent disinfectant, peracetic acid (PAA). In the presence of AcT and its two substrates, propylene glycol diacetate and H₂O₂, sufficient and continuous PAA is generated over an extended time to kill a wide range of bacteria with the enzyme dissolved in aqueous buffer. For extended self-disinfection, however, active and stable AcT bound onto or incorporated into a surface coating is necessary. In the current study, an active, stable and reusable AcT-based coating was developed by

SUBMITTER: Wang LS 

PROVIDER: S-EPMC8203652 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature